Epstein (1924-2008) Fall 2008 Remberlee S-Heuson The Mount Desert Island Biological Laboratory Franklin H. Epstein, M.D. 1924 - 2008 Investigator, Teacher, Master Clinician Franklin Harold Epstein, M.D., a mainstay of the on to work in his Beth Israel-Deaconess lab, said "He MDIBL community for 40 years, died on was an incredibly compassionate and generous November 5, 2008 in Boston. He was human being. He really brought out the best 84 years old and actively engaged in intellectually. I learned from him about biomedical research and teaching at science, but he was also an inspiring MDIBL. He was widely considered role model as a person." one of the giants of metabolism Dr. Epstein went to Yale and nephrology. School of Medicine after receiving "Frank Epstein had an enor- his bachelor's degree summa cum mous influence on every aspect laude from Brooklyn College and of the lab, an influence not seen received his medical degree in since the days of Dr. Homer 1947. He completed his internship Smith, fifty years earlier," said Dr. and residency at the New Haven John Forrest, Director of MDIBL Hospital, where he came under the and a former trainee of Dr. Epstein. influence of Dr. John P. Peters. Dr. "He attracted dozens of investigators Peters, regarded by many as the lead- to MDIBL and trained multitudes of high ing American physician/scientist of his school students, undergraduates, medical stu- time, explored the pathophysiology of water dents and fellows at the bench, each of whom and electrolytes in human disease. Eventually, Dr. recall him as dramatically influencing their lives. Epstein succeeded Dr. Peters as chief of the Division Frank Epstein exemplified the ideal physician: an of Metabolism at Yale. investigator, a teacher, and a master clinician, and After a fellowship at Boston University Medical he encouraged this model in others. He was a bril- School in cardiology and a period of time in the liant scientist with the uncanny ability to probe the United States Army, first at Walter Reed Army essence of any research question." Hospital and then at the First General Dispensary at Katie Hessler, who first worked with Dr. Epstein Fort Richardson, Alaska, Dr. Epstein returned to Yale as a Hancock County Scholar at MDIBL and went in the Division of Metabolism continued on page 3 Franklin H. Epstein, M.D. 1924 - 2008 (continued from page 1) and the Department of Medicine. Here he was successively promoted from the rank of assistant professor to full professor. He was one of the first recipients of the Blake Award at Yale for outstanding teaching of the bio- medical sciences. In 1972 he moved to head the Thorndike Memorial Laboratory and the Harvard Medical Unit of Boston City Hospital. One year later he joined the Beth Israel Hospital as Chairman and Physician-in-Chief of its Department of Medicine. He remained at the hospital, now known as the Beth Israel Deaconess Medical Center, ever since. Dr. Epstein (left) and his MDIBL colleague Dr. Richard Hays in the Kidney Shed Dr. Epstein received many national and interna- that you get a better answer if you ask a better question. tional honors for his accomplishments in nephrology, It was Dr. Epstein's wise counsel that kept MDIBL on including the John P. Peters Award of the American the right path during some of our most challenging Society of Nephrology in 1985, the David Hume times." Award of the National Kidney Foundation in 2003, At MDIBL, Yale, and Harvard, Dr. Epstein's the Bywaters Award from the International Society research encompassed ion transport in marine of Nephrology, and honorary degrees from Oxford species, the physiology of the renal medulla, disorders University and the Medical Academy of Gdansk, of urinary concentrating ability, mechanisms of Poland. acute renal failure, disorders of water, sodium, and At MDIBL he studied the comparative physiology potassium, and medical complications of pregnancy of salt and water homeostasis in lower vertebrates including preeclampsia. He wrote and spoke pas- and made many seminal observations. He served as sionately about the physician's role in caring for president of the Lab for 10 years. Dr. Epstein was a the dying patient. He is the author of approximately rigorous thinker who had the highest expectations of 400 papers, reviews, and chapters, including a histo- himself and others. At weekly Monday morning 8 ry of MDIBL from 1898-1998 entitled A Laboratory a.m. outdoor seminars on the lab point, which he by the Sea. He was a longstanding editor of the text- organized for 25 years, he asked challenging questions book Harrison's Principles of Internal Medicine and that inspired the curiosity of all in the audience, from of the New England Journal of Medicine. students and trainees to the presenter. He was a cheerful and enthusiastic man, who had Terence Boylan, Chair of the MDIBL Board of an extraordinarily tuneful whistle heard throughout Trustees, was a young boy when he first met Dr. MDIBL and a fine tenor voice. He sang constantly, Epstein. "I had a chance to observe, for decades, the and his voice will continue to fill the hearts of his enormous impact his teaching and his example had on family and friends. his students and his colleagues. What I and my fellow He leaves his wife, Sherrie (Spivack); his four lab kids will remember, though, was his kindness and children, Mark Epstein of New York; Ann Epstein of patience, and how he gently encouraged us to think Brookline, Mass.; Sara Epstein of Winchester, things through. Later, when I came to the Board of Mass.; and Jonathan Epstein of Radnor, Pa.; and Trustees, that same thoughtfulness was a guiding nine grandchildren. inspiration in approaching problems, always mindful PAGE SECTION 1 Obituaries Franklin H. Epstein, M.D. BAR HARBOR - Dr. Dr. Epstein. received He wrote and spoke passionately Franklin Harold Epstein, many national and inter- about the physician's role in caring former president of the national honors for his for the dying patient. He is the au- Mount Desert Island Bio- accomplishments in thor of approximately 400 papers, logical Laboratory in Bar nephrology, including the reviews, and chapters, and he was a Harbor and William Ap- John P. Peters Award of long-time editor of "Harrison's Prin- plebaum Professor of the American Society of ciples of Internal Medicine," text- Medicine at Harvard Nephrology in 1985, the book of the New England Journal of Medical School, died on David Hume Award of Medicine. Dr. Epstein trained a gen- Nov. 5, 2008. He was 84 the National Kidney eration of medical students, resi- years old and actively en- Foundation in 2003, the dents and fellows in internal medi- gaged in biomedical re- Bywaters Award from the cine, and was known as an search, teaching and clini- Franklin H. International Society of inspirational orator and teacher, and cal care until just a few Epstein, M.D. Nephrology, and hon- as a caring bedside clinician, a leader weeks ago. orary degrees from Ox- by example. Dr. Epstein was a rigor- Dr. Epstein went to ford University and the ous thinker who had the highest ex- Yale Medical School after receiving Medical Academy of Gdansk, pectations of himself and others. Al- his bachelor's degree summa cum Poland. He was a summer investiga- though on medical rounds he asked laude from Brooklyn College, and tor for 40 years at the Mount Desert intimidating and exacting questions, graduated from Yale in 1947. After a Island Biological Laboratory he was loved as a gentle and kind fellowship at Boston University (MDIBL) in Salisbury Cove, where teacher. He was a cheerful and en- Medical School in cardiology and a he studied the comparative physiol- thusiastic man, who had an extraor- period of time in the United States ogy of salt and water homeostasis in dinarily tuneful whistle and a fine Army, Dr. Epstein returned to Yale in lower vertebrates, and trained many tenor voice. He sang constantly, and the Division of Metabolism and the undergraduates, medical students his voice will continue to fill the Department of Medicine. There he and fellows. hearts of his family and friends. was successively promoted from the He was a long-time trustee, mem- He leaves his wife, Sherrie (Spi- rank of assistant professor to full ber of the executive committee and vack); four children, Mark Epstein professor, before going to Boston in served as president of MDIBL from of New York, Ann Epstein of Brook- 1972 to head the Thorndike Memor- 1986 to 1995. His research encom- line, Mass., Sara Epstein of Winches- ial Laboratory and the Harvard passed the physiology of the renal ter, Mass., and Jonathan Epstein of Medical Unit of Boston City Hospi- medulla, disorders of urinary con- Radnor, Penn.; and nine grandchil- tal. One year later he joined the Beth centrating ability, mechanisms of dren. Israel-Deaconess Hospital as chair- acute renal failure, disorders of wa- Contributions in Dr. Epstein's man and physician-in-chief of its ter, sodium, and potassium, the memory may be made to the Mount Department of Medicine, and re- movement of ions across marine ep- Desert Island Biological Laboratory, mained at what is now the Beth Is- ithelia, and medical complications of P.O. Box 35, Salisbury Cove ME rael-Deaconess Medical Center. pregnancy including preeclampsia. 04672 oronline at mdibl.org. EPSTEIN/1: Mentor mourned 11/13/2008 MDIBL and training multitudes deliberative thinking," said of high school students, under- MDIBL president Terence Boy- graduates, medical students and lan. fellows at the bench," said John In 1998, on the commemora- Forrest, MD, MDIBL director. tion of MDIBL's 100th anniver- One such student was Katie sary, Dr. Epstein published a Hessler. In the summers follow- history of the lab. At the dedica- ing her junior and senior years at tion of the lab's new research Ellsworth High School, Ms. building last summer, Dr. Ep- Hessler worked in Dr. Epstein's stein pointed out that although lab. In a 2003 interview, she said we tend to think of the present Bio lab that working in the lab had not day as a time of great scientific only provided her with an op- progress, the waning years of portunity to conduct real-world the 19th century showed enor- mourns research, but had also given her a mous progress. "We're the in- good understanding of what re- heritors of that tradition and of search and lab work involves. three great scientists - Charles Epstein In late September of this year, Darwin, Gregor Mendel and Dr. Epstein taught an intensive Claude Bernard," said Dr. Ep- weeklong workshop in compara- stein. Dr. Bernard, a French By Anne Kozak tive physiology for junior resi- physiologist, "enunciated the dents from Beth Israel Dea- principal on which this lab is BAR HARBOR - Long- coness Medical Center in built: the constancy of the inte- time Mount Desert Island Bi- Boston, where Dr. Epstein had rior environment is the condi- ological Laboratory re- an appointment. tion of a free and independent searcher and mentor, Frank "Frank was one of the lab life." The lab's longstanding Epstein, 84, died on Nov. 5 people I most respected. He focus on the kidney is particu- after a short illness. Dr. Ep- treated students as equals who larly significant, for "it is the stein, the Applebaum Profes- were worth listening to and tak- kidney," said Dr. Epstein, "that sor of Medicine at Harvard ing seriously, but he also didn't maintains the internal environ- Medical School, spent 40 serve up platitudes and was will- ment. years at MDIBL, including 10 ing to criticize poor thought," "In this atmosphere of scien- as-president of the lab. said Chris Petersen, a marine bi- tific progress in the late 19th "Dr. Epstein was a main- ologist at College of the Atlantic century, the great marine labora- stay of MDIBL. He had an and the MDIBL liaison. tories were founded in Naples, enormous influence on every The many tributes from his Italy, Plymouth, England, Woods aspect of the lab, attracting colleagues at MDIBL, Harvard Hole, Friday Harbor in Washing- dozens of investigators to Medical School and Beth Israel ton, and Mount Desert Island see EPSTEIN page 14 include comments about Dr. Ep- Biological Laboratory," said Dr. stein's ability to ask probing Epstein. questions. "I am very proud of this "I've known Dr. Epstein since building," said Dr. Epstein. "It I was a boy, so I've had the exemplifies and personifies these chance, for decades, to observe traditions of the 19th century. the enormous impact his teach- Our task is to continuously grow ing, and his example, had on his in quality but not much more in students and colleagues - espe- quantity so that these traditions cially by example in teaching the continue See full obituary on value of precision and careful, page 4. 6/1 11438 Mount Desert Island Biological Laboratory. Many years ago, before the National Park was thought of or steps had been taken to secure the public lands from which it sprang, I purchased on my own account, interested in boating and looking forward to the future, one of the best wharfage points on Frenchmans Bay, an ancient lava flow extending out into deep water. It had been a part of the old Thomas Emery farm at Salisbury Cove, one of the earliest on Mount Desert Island. To its eastward, with a little sheltered bay between, another lava flow extended similarly out into the same deep current and had upon it, fronting upon the old highway to the Bridge, the old Emery farmhouse, a property of some nine or ten acres in extent which could be had at reasonable ex- pense. The site, the shore and the old building interested me, and when, just at that time, there was talk among the summer residents at Bar Harbor of establishing a memorial to Dr. S. Weir Mitchell of Philadelphia, who had died the winter before, and (Jan. 4,(1914) 2. some monument was proposed upon the Village Green, I suggested that something of living interest might better be created instead. Dr. Mitchell, an intimate friend always at our house in earlier days, had been one of the executive committee on the board of trustees of the Carnegie Institution at Washington and had told me, with great interest, of the work that they were doing at a marine biological station established by the institution at Key West, off the coast of southern Florida. This was a matter which had interested me greatly, and what I proposed should be done in Dr. Mitchell's memory was the purchase of the old Emery farm at Salisbury Cove, with its uniquely favorable opportunity for such research, its picturesque character and inter- esting old house, for the establishment of similar work, when funds for it could be found, in our northern waters, fed by the pure Arctic current, in striking contrast to that of the station in which Dr. Mitchell had been so much interested at Key West. 3. The idea took root. Dr. Robert Abbe, equally beloved and with his own beautiful home at Brookend, where the water of Duck Brook comes down to meet the sea, took hold of it with enthusiasm, writing an eloquent appeal, and funds were raised before the summer ended that enabled us to buy the land. I held it as trustee for several years, awaiting oppor- tunity to carry out the plan. In the spring of 1916, being then in Washington seeking acceptance by the Government of our National Park land, I wrote, after consulting with the President of the Carnegie Institu- tion, whom I had interested in our project, to Dr. Alfred Mayer, professor of Ichthyology -- fish life -- at Princeton, who had had charge of the work the Institution had been doing at Key West and asked him to come down and be my guest at Bar Harbor, toward the end of June, to look our opportunity over from the biologic point of view and make report upon it. He accepted and had already arrived at Bar Harbor when I returned from Washington, later than I had expected but with the National Park, in its first form as a National Monument, secured. 4. At the meeting held at the Building of Arts, presided over by President Eliot, to celebrate the Government's acceptance of our tract, Dr. Mayer was one of the principal speakers, making a most favorable report upon the site at Salisbury Cove and the wealth of marine invertebrate forms contained in the pure, cool waters off it. Returning to Princeton, he made report of our undertaking to his colleagues there with the result that I presently received a letter from Professor Ulric Dahlgren, in the same department with Dr. Mayer at the University, saying that he and some others in association had been carrying on a work similar to what our plan proposed for several years on an island in Casco Bay, at the mouth of the Kennebec, and suggesting that it would be desirable not to have two enterprises of similar aim studying these northern waters. I wrote him in reply, saying that I quite agreed with him that a single institution in which all work might be combined would be preferable to a divided interest, but that I thought we had from every point of view the better opportunity, and I suggested that he and his associates join with us at Salisbury Cove. 5. A meeting at Princeton followed the next winter, the plan was approved, and a sum raised sufficient for the cost of the r emoval from Casco Bay to Salisbury Cove and the establishment there of a joint enterprise upon a simple basis, with a boat for collecting, tanks for the study of specimens, and a pump with hard rubber fittings inert to chemical action of the ocean waters to supply water from the deep, pure channel off Emery Point. The first start was made in the summer of 1922, now sixteen years ago and every summer since work of the most interesting and varied character has been conducted at the Laboratory, research work only being carried on. Lands adjoining along the shore have been purchased for housing by the Association and by individual workers, and a colony has been established founded upon a common interest in biological study. The library has grown, a better boat has been secured and the buildings en- larged. The way lies open for carrying on a permanent work of continuously increasing value. [G.B.DORR] 3/19/04 frehlin Extrain UD Intervrew MPI BL Seated on bench overlooky neaches Bay, 3-4.0a. - Qst from FE (A) Dorr's Harved club affiliation (B) i Classinate? (c) What kind of lean was he? - Statesmalike ? - persistent ? - Chainer ? (d) Family had prised (connection? - political? (e) Graduate with at Haward 2 (f) - - FE encouraged me to write agree c July Goldstain is 1850-1926 - FE - Moden timefies Science in (deate evolutic 1860's 1880's. CWE(.6t). of of - (Q Bouditch in leadicine at Housed (b) Psyclusal research t the experimentation of era. - FE stessed importance of faily connection Baston as 4 "After L America 4 all that estrited, lop they expectation of decomplishment F 1/7/16 Franklin Harold Epstein, M.D. May 5, 1924 - November 5 2008 This year we mourn the passing of Franklin Harold Epstein, M.D, former president of the Laboratory. Over the course of the past forty years Mount Desert Island Biological Laboratory has been privileged and fortunate to have him among its investigators. He was perhaps the single major influence in the course of the scientific work at the laboratory during that time. His presence, at many different levels, enhanced the science, visibility and prestige of the laboratory. As an investigator he was interested in the many different aspects of salt and water homeostasis. He participated in the governance of the laboratory as a member of most of the consequential committees: scientific advisory committee, elected member of the executive committee, long-range planning committee, and nominating committee. He was trustee, vice president, and president of the laboratory. He was instrumental in increasing the visibility of the laboratory, not only nationally but also locally. Building on the early efforts of the laboratory to invite local participation he opened up the laboratory to the local community. He invited national participation and obtained recognition for the laboratory from private foundations. His wisdom and advice was sought and freely given to all members, young and old, in the laboratory community. His scientific interests and lines of investigation launched the scientific careers of some of the members of the laboratory and inspired many others to pursue fruitful projects. Born in Brooklyn, New York, he attended Brooklyn College where he graduated summa cum laude in 1944. He attended Yale University School of Medicine graduating cum laude in 1947. At Yale University he came under the inspiration of John P. Peters who would become a deciding influence on his career. He trained at Yale, and was a fellow at the Department of Medicine at Boston University. During the Korean War he was Captain in the Medical Corps of the US Army, initially an Instructor at the Army Medical Service Graduate School, Walter Reed Army Medical Center, and later stationed at Fort Richardson, Alaska. After his service in the army he joined the faculty at Yale University School of Medicine where he rose in rank from Assistant Professor to Professor and succeeded Dr. Peters as Chief of the Section of Metabolism. He then became the Chairman of the 2 &4 Harvard Medical Services and Department of Medicine at the Boston City Hospital and later Hermann L. Blumgart Professor of Medicine and Chairman of the Department of Medicine at Beth Israel Hospital and Harvard Medical School. During that time, until 1993 he was also Director of the Nephrology Division at the Beth Israel Hospital. At the time of his death he was William Applebaum Professor of Medicine at Harvard Medical School. He was married to Sherrie (Spivak) Epstein, and was the father of four children: Mark, Ann, Sara and Jonathan. All of the children experienced the excitement of research at MDIBL and went on to obtain doctoral degrees inspired, no doubt, by Frank's example. He trained and mentored over a hundred fellows, students, and faculty. Most, if not all, of the physicians he trained went on to develop successful academic careers of their own across the country and throughout the world achieving positions as faculty members, Section or Division Chiefs, Department Chairs, Deans, and University Presidents. He received more than seventy awards and recognitions over his long career. Among them the Francis G. Blake Award from Yale University, the John P. Peters Award from the American Society of Nephrology, the Bywaters Award from the International Society of Nephrology, and the David Hume Award from the National Kidney Foundation. He was also a Fellow of the American Association for the Advancement of Science. He was the epitome of the physician scientist. The scope of his scientific interests was breathtaking. Early in his career he investigated the management of congestive heart failure and the management of circulatory failure in myocardial infarction. He was interested in hypertension, its management and the consequences of treatments. He had a longstanding interest in complications of pregnancy including eclampsia. He studied the effect of hormones on the kidneys. Later he studied salt and water transport, renal metabolism and the interplay between renal metabolism and function. The current underlying his investigations was the insights that they offered on the physiology of the systems and the implications for clinical care. Observations made while seeing patients or during case presentations in rounds often led to questions that he suggested to junior faculty members, sometimes not SO junior, to investigate. But more than just proposing the investigation he would indicate ways to approach it. Once the question was raised and the way to solve it decided he would pursue relentlessly the completion of the project. He was a teacher of uncommon clarity. He presented and discussed the issues in a way that everybody could understand. He had the gift of rapidly and correctly assessing the level of complexity that was appropriate to the audience and adjusted his teaching to that. He was excellent at explaining complex issues, many times resorting to illustrative analogies. His lectures were always well attended and well received. Lectures and presentations offered a unique opportunity to witness his capacity to address problems and offer creative insights. He would sit patiently throughout lectures, sometimes turning around his pocket knife in his hands, often looking down, bowing his head giving the impression that he was not that interested in the topic presented. When the lecture ended and opened for questions he would ask questions that revealed that he not only had paid attention to what was discussed but more often than not suggested new ways to approach the issue and occasionally exposed the flaws in the premises or reasoning of the exposition. This he never did in a confrontational way, more as a discussion, a conversation even, as if he wanted to clarify things, and when it was over the speaker would, more often than not, thank him for his insights and conclusions that many times were different from those presented. When he wanted a member of the faculty to work on something that initially seemed unappealing, he would begin by enunciating the problem and asking for input. He would slowly build up the interest in the project by listening and discussing ways to approach it, likelihood that the different lines of inquiry would give clear results, and pro and cons of the different paths. Finally he would suggest that with all the thinking and different insights that the faculty member had expressed he or she was the natural person to address that enterprise. Perhaps the outstanding characteristic of his career is the interest he expressed in all the problems that were presented to him. He would listen carefully, only interrupting for clarification but he would correct mistakes or misinterpretations, and ask for clear demonstration that the observations were correct. He would then offer suggestions and indicate how he would approach the questions or who to contact for further suggestions, information, or technical help. He gave his advice freely, encouraging people to pursue research avenues he suggested. He often would think of a question and then look for the person who could do investigation. Over the course of forty years, starting in 1968, he investigated the way fish manage salt and water. Bony fish that move between fresh and salt water manage their salt by increasing the excretion of salt by the gills in salt water and cutting off its excretion in fresh water. The regulation of this phenomenon was not known. His studies in Fundulus heteroclitus and Anguilla rostrata demonstrated that cortisol induced the changes necessary for the movement from fresh to salt water and prolactin mediated those required for the return to fresh water. The activity of Na-K-ATPase in the gills increased when the fish moved to salt water and decreased when it was adapted to fresh water, suggesting that it mediated the movement of salt into the water. However, the pump was located on the blood side of the cells that secreted salt, the wrong side if sodium was to be secreted into the ocean. Sodium could not possibly leave the cell into the ocean through the apical surface of the cells and could not be the ion excreted by the secretory cells of the gills. From these experiments arose the concept of the cotransport of chloride and sodium through a transport molecule that was later characterized in the rectal gland of the Squalus acanthias and found to require also potassium. This was the sodium, potassium two chloride cotransporter, the target of furosemide and related diuretics, later cloned out of the rectal gland of the shark. The richness of the rectal gland of the shark in Na-K-ATPase offered a singular opportunity to examine the role of this enzyme on salt balance in fish. Sharks cannot maintain salt homeostasis by excreting salt through the gill as bony fish do. The organ responsible for the excretion of salt in the shark is the rectal gland that is rich in Na-K-ATPase. Initial studies were hampered by the low rate of secretion of salt by the gland. With the realization that the rectal gland was under humoral control the organ could be studied and the nature of the secretory mechanism was found to be similar to that of the gills of bony fish. The ion transported across the cell was chloride and its secretion was mediated indirectly by Na-K-ATPase. The concept of secondary active transport, powered by Na-K-ATPase emerged from these studies. The mechanisms regulating the secretion of chloride were found to be quite complex. The expansion of the extracellular space caused the release of a natriuretic peptide from the heart of the shark. The natriuretic peptide circulated to the rectal gland where it directly stimulated the rectal gland cells and induced the release of vasoactive intestinal peptide from nerves within the gland, that, in turn also stimulated the cells. The secretion of chloride by the rectal gland of the shark was regulated by humoro-neural mechanism. His scientific activities in the laboratory were many more than his individual studies. One additional accomplishment, valued by all, was the organization and speaker recruitment for the Monday morning seminar. This seminar was for many years a learning activity, a source of information, and gathering place for all members of the laboratory community. His legacy is not only that of gifted investigator, a caring physician, an inspiring teacher, a wise and thoughtful manager but for all of those who came in contact with him there is also that dimension of a kind, gentle, generous man that enriched us all. Gentle in the way he treated those who came to him for instruction, kind in the way he treated everybody around him, and generous in his freely given flow of ideas and supportive advice. Those of us who had the fortune to know him and work with him will always carry him in our hearts. Patricio Silva, M.D. Professor of Medicine Chief, Section of Nephrology and Kidney Transplantation Medical Director, Kidney Transplant Program Temple University Epp, Ronald From: fepstein@bidmc.harvard.edu Sent: Thursday, August 28, 2003 5:53 PM To: ( Epp, Ronald Subject: RE: George Dorr & J.W. Burger Essay It was really a pleasure to meet you and to talk with you. My Boston address at my office is: Dana 517, BIDMC East, 330 Brookline Avenue, Boston, MA, 02215. My home address is: 294 Buckminster Road, Brookline, MA, 02445. Frank Epstein Original Message From: Epp, Ronald To: fepstein@bidmc.harvard.edu Cc: Epp, Ronald Sent: 8/28/03 4:02 PM Subject: George Dorr & J.W. Burger Essay Dear Franklin, I want to thank you for your time, knowledge, and magnanimity this past Monday when we met at the MDIBL. Your discussion of MDIBL history within the broader framework of biological research since the end of the 19th century provided a helpful context. I will follow your suggestion to speak with Nancy Howland at the Jesup Library regarding the original documents that you used in your historical for the centennial volume. The J.W. Burger "Pioneer Days" essay that you lent me will be posted tomorrow in care of your Cambridge address. Thank you for loaning it to me. When I get to the stage of drafting the chapter on Dorr's interactions with the MDIBL might I contact you about critiquing it? I enjoyed meeting Sherrie as well. Perhaps we can meet once again on MDI. Ronald H. Epp, Ph.D. 47 Pond View Dr. Merrimack, NH 03054 603-424-6149 Original Message From: fepstein@bidmc.harvard.edu [mailto: fepstein@bidmc.harvard.edu Sent: Thursday, August 14, 2003 9:01 PM To: Epp, Ronald Subject: RE: MDIBL & George Dorr How about in the main office of the MDIBL (go down the road to its end, on the right) at 10 am, on the 25th of August. Frank Epstein Original Message From: Epp, Ronald To: fepstein@bidmc.harvard.edu Sent: 8/14/03 3:27 PM Subject: RE: MDIBL & George Dorr Dear Dr. Epstein, 1 If this time slot is still available for meeting with you at MDIBL, I'd like to schedule an appointment. Where might we meet? Ronald H. Epp, Ph.D. Director of Shapiro Library Southern New Hampshire University Manchester, NH 03106 603-668-2211, ext. 2164 603-645-9685 fax ---Original Message From: fepstein@bidmc.harvard.edu [mailto:fepstein@bidmc.harvard.edu] Sent: Saturday, August 02, 2003 9:14 AM To: Epp, Ronald Subject: RE: MDIBL & George Dorr I will be here on Aug 7 and 8 but have committments both afrternoons. How about 10 am Aug 25? F.H. Epstein Original Message From: Epp, Ronald To: fepstein@bidmc.harvard.edu Cc: Epp, Ronald Sent: 8/1/03 4:00 PM Subject: RE: MDIBL & George Dorr Dear Dr. Epsietin, Thanks for responding SO enthusiastically to my inquiry. Yes, I have made extensive use of the Dorr Papers in the Jesup Library, the artifacts in the Bar Harbor Historical Society, the library at the Jackson Lab, etc. I wanted to let you know that I will be on MDI August 7 & 8 and again on the 25th and for additional research. If you are available on any of these dates perhaps I could visit you at the MDIBL. If one of these dates is convenient please propose a time. I'll bring along my files of archival material relative to the formation of MDIBL which may include documents that you wish to add to your historical holdings. Sincerely, Ronald H. Epp, Ph.D. Director of Shapiro Library Southern New Hampshire University Manchester, NH 03106 603-668-2211, ext. 2164 603-645-9685 fax Original Message From: fepstein@bidmc.harvard.edu [mailto:fepstein@bidmc.harvard.edu] Sent: Thursday, July 17, 2003 8:56 PM To: Epp, Ronald Subject: RE: MDIBL & George Dorr Thanks for your e-mail and please let me know when you will be here, I'd like very much to meet you. I will go over my files to see if there is anything of interest The Jesup Memorial Library in Bar Harbor would be worth contacting; they have an extensive historical file. I do have a framed letter from George Dorr about the formation of the 2 Mount Desert Island Biological Lab, which you can certainly see. Franklin H. Epstein, M. D. Original Message From: Ronald Epp To: fepstein@caregroup.harvard.edt Cc: c.epp@snhu.edu Sent: 7/17/03 1:49 PM Subject: MDIBL & George Dorr Dear Professor Epstein: For the past three years I have been researching the life of George B. Dorr in preparaion of an intellectual biography that extensively relies on archival material previously unutilized in many of the popularized accounts of Dorr's role in creating Acadia National Park. of course I am aware of the MDIBL centennial history. The Park Archives, National Park Service Historical Collections, and the Rockefeller Archive Center are among the scores of archival resources that I have utilized. I contacted Mike McKernan recently to determine whetther MDIBL might have archival material relative to Mr. Dorr. In mid-May I visited the laboratory and Mike showed me a solitary notebook which contained the early deeds transferring ownership from Mr. Dorri Mike said that this was unaware of any other MDIBL archival materials. Might there be additional manuscript resources available for my inspection? In several weeks I will be returning to MDI to give a presentation celebrating the 75th anniversary of the Abbe Museum and would enjoy meeting you and examining any archival materials germane to the history of MDIBL in the 1920's and '30's. I very much appreciate your attention to this matter. Ronald H. Epp, Ph.D. Director of Shapiro Library Southern New Hampshire University Manchester, NH 03106 603-668-2211, ext. 2164 603-645-9685 fax 3 Frank Epstein & Ron Epp - Sent - Verizon Yahoo! Mail Page 2 of 2 Mail Contacts Calendar Notepad What's New? Mobile Mail Options Check Mail Compose Search Mail Search the Web See your Credit Previous Next I Back to Messages Mark as Unread Print Score Free Delete Reply Forward Move Folders [Add Edit] Frank Epstein & Ron Epp Wednesday, December 10, 2008 11:23 AM Inbox (5) From: "ELIZABETH and RONALD EPP" Drafts (5) To: amk@coa.edu cc i. Fudith Sent Spam (3) [Empty] Dear Anne, Trash [Empty] Last month when I learned from Judith S. Goldstein of the unexpected death of Frank Epstein, My Folders [Hide] I was filled with remorse. Later when I read your account of in his legacy in The Islander I DorrBiblio (5) resolved to write and express my appreciation for your insights. A family crisis took me away to Pennsylvania and I've only recently returned to catch up on delinquent matters. DorrBio2008 (34) Eliz messages (6) Frank took me under his wing early in my research on the Dorr biography.l remember talking with him in August 2003 while seated on a shoreline rock face at MDIBL. As a Harvard Horseshoe Pond graduate he provided direction for how I should undertake tracking the Dorr documentation in Member Informa the Harvard archives. Later we met nearby at his home where I updated him on my progress Ron Archives (31) and again he raised questions about Dorr's psychological stability, leading me to think about whether he suffered from bipolar disorder (to which I have concluded that he did not). In all our discussions he was thoughtful, caring, supportive, and broadly incorporative of ideas from Search Shortcuts every imaginable discipline. My Photos At his invitation we both gave August 2005 MDIBL presentations on "George B. Dorr and the My Attachments Early Development of MDI Scientific and Cultural Institutions," our last face-to-face contact. Afterward there were occasional email updates. Dr. Epstein was always enthusiastic about the ADVERTISEMENT need to bring Dorr's life before the attention of a public that increasingly was fulfilling his Home Loan and Rate Updates successor's prophesy--letting Dorr slip into an historical abyss. Frank motivated me to be as persistent as Dorr--and himself--in developing the cultural and natural resources of Mount LendingTree Desert Island. Unfortunately, he died without knowing that the Library of American Landscape History and the University of Massachusetts Press will publish the biography in the near future. WHEN BANKS COMPETE YOU WIN I will miss him! Refinance $400,000 Fixed for $2,367/month Wishing you well. *terms and conditions apply Ron Epp eppster2@verizon.net Delete Reply Forward Move Previous Next I Back to Messages Select Message Encoding I Full Headers Check Mail Compose Search Mail Search the Web Copyright © 2008 Yahoo! Inc. All rights reserved.Copyright/IP Policy I Terms of Service Help NOTICE: We collect personal information on this site. To learn more about how we use your information, see our Privacy Policy http://us.mc842.mail.yahoo.com/mc/showMessage?fid=Sent&sort=date&order=down&st.. 12/10/2008 Franklin H. Epstein, M.D. Page 1 of 2 MDI Biological Lab GENERAL INFORMATION HOME RESEARCH EDUCATION COURSES/CONFERENCES NEWS/EVENTS GENERAL INFO ABOUT MDIBL Franklin H. Epstein, M.D. 1924 - 2008 2007 Annual Report Latest Newsletter BOARD OF TRUSTEES AND OFFICERS LABORATORY GROUNDS Labs and Cottages Campus Map (pdf) SEASONAL SCIENCE Investigators Information for Families CAREERS DIRECTORY Remembrances of Dr. Epstein will be posted below. Please send your own remembrances. TRAVEL INFORMATION FORMS AND DOCUMENTS Franklin H. Epstein, M.D. William Appelbaum Professor of Medicine Harvard Medical School HISTORY OF THE LAB Boston, MA May 5, 1924-November 5, 2008 INVESTIGATORS Dr. Franklin Harold Epstein, William Applebaum Professor of Medicine at Harvard Medical PUBLICATIONS School, died on November 5, 2008. He was 84 years old and actively engaged in biomedical research, teaching, and clinical care until just a few weeks ago. Investigator Publications Dr. Epstein went to Yale Medical School after receiving his bachelor's degree summa MDIBL Publications cum laude from Brooklyn College, and graduated from Yale in 1947. He completed his internship and residency at Yale-New Haven Hospital, where he came under the PHILANTHROPY influence of Dr. John P. Peters, the leading American physician/scientist of that time who explored the pathophysiology of water and electrolytes in human disease. Eventually, PUBLIC TOURS Dr. Epstein succeeded Dr. Peters as chief of the Division of Metabolism at Yale. PUBLIC EVENTS After a fellowship at Boston University Medical School in cardiology and a period of time in the United States Army, first at Walter Reed Army Hospital and then at the First General Dispensary at Fort Richardson, Alaska, Dr. Epstein returned to Yale in the Division of Metabolism and the Department of Medicine. Here he was successively promoted from the rank of assistant professor to full professor, before coming to Boston in 1972 to head the Thorndike Memorial Laboratory and the Harvard Medical Unit of Boston City Hospital. One year later he joined the Beth Israel Hospital as chairman and Physician-in-Chief of its Department of Medicine and has remained at Beth Israel, now the Beth Israel-Deaconess Medical Center, ever since. Dr. Epstein has received many national and international honors for his accomplishments in nephrology, including the John P. Peters Award of the American Society of Nephrology in 1985, the David Hume Award of the National Kidney Foundation in 2003, the Bywaters Award from the International Society of Nephrology, and honorary degrees from Oxford University and the Medical Academy of Gdansk, Poland. He was a summer http://www.mdibl.org/info/epstein.shtml 11/9/2008 Franklin H. Epstein, M.D. Page 2 of 2 investigator for 40 years at the Mount Desert Island Biological Laboratory (MDIBL) in Maine, where he studied the comparative physiology of salt and water homeostasis in lower vertebrates and trained at the bench many undergraduates, medical students and fellows. He was a long standing Trustee and member of the Executive Committee and served as President of MDIBL for 10 years. His research encompassed the physiology of the renal medulla, disorders of urinary concentrating ability, mechanisms of acute renal failure, disorders of water, sodium, and potassium, the movement of ions across marine epithelia, and medical complications of pregnancy including preeclampsia. He wrote and spoke passionately about the physician's role in caring for the dying patient. He is the author of approximately 400 papers, reviews, and chapters, and he was a longstanding editor of Harrison's Principles of Internal Medicine Textbook and of the New England Journal of Medicine. Dr. Epstein trained a generation of medical students, residents, and fellows in internal medicine and was known as an inspirational orator and teacher, and as a caring bedside clinician: a leader by example. Dr. Epstein was a rigorous thinker who had the highest expectations of himself and others. Although on medical rounds he asked intimidating and exacting questions, he was loved as a gentle and kind teacher. He was a cheerful and enthusiastic man, who had an extraordinarily tuneful whistle and a fine tenor voice. He sang constantly, and his voice will continue to fill the hearts of his family and friends. He leaves his wife, Sherrie (Spivack), his four children, Mark Epstein of New York, Ann Epstein of Brookline, Ma., Sara Epstein of Winchester, Ma., and Jonathan Epstein of Radnor, Pa., and nine grandchildren. A funeral service will be held on Sunday, November 9, 2008 at 10:30 a.m. at the Temple Ohabei Shalom, 1187 Beacon St, Brookline, MA, followed by burial at Sharon Memorial Park in Sharon, MA. Visiting after the burial is at 294 Buckminster Rd., Brookline MA, and on Monday and Tuesday evenings (Nov. 10, 11) from 7 p.m. - 9 p.m. The family requests that in lieu of flowers, donations be made to the Mount Desert Island Biological Laboratory, Salsbury Cove, ME. HOME RESEARCH EDUCATION COURSEs/CONFERENCES NEWS/EVENTS GENERAL INFO Careers I Directory I Sitemap I Contact Us | P.O. Box 35, Old Bar Harbor Road, Salisbury Cove, ME 04672 I 207.288.3605 Copyright © 2008, MDI Biological Laboratory http://www.mdibl.org/info/epstein.shtml 11/9/2008 Stannie Dr Epstai, MOIBL t his home 8/25/03 1. Re Americ Hist Soc. - check Connee Jellyson in Phone Book 2. States Enphases on selects ~ 4 high gualit research selinsts when careers later were phenomalf successful, esp. is kidney function 3. Check Howard Anlines is MDI C / Eliotor Osya of MOIBL lifer to Eystern 4. Rivinide Press 5. Hang Medica Group Minot, Fraces Peobal stidered minot. / Epstein have successfr. Boston (of Hospital moing photos of Unit P.x Due at northeal Harbor 8/19/04 Frehlin Epistein ,UD. Interview MPI BL Copy Seated on bench overlooky neach Bay, 3-4.00. - Qst from FE (B) i Classmate? (A) Dorr's Harved club affiliation? (c) What kind of lean was he? - Statesmalike ? - peristent - Chainer ? (d) Family had pound (connections? - political? (e) Graduate with at Haward 2 (f) - FE - encouraged me to write agreed c July Goldstain is 1850-1926 - FE emphasize evolutre of Moden timefieur (deate at cweliet). in 1860's - 1880's. (Q Bouditch in medicine at Housed (b) Psyclusal reseach t the experimentation d of-era - FE stressed importance of faing connection Bastan as "Athers 4 of America I all that estrited cop capicitation of decomplishment. 8/19/04 Frablin Epstain UD. Interview MPI BL Seated on bench overlooky neacher Beg, 3-4.0a. - QJ from FE (B) i Classwate? (A) Dorr's Harvard club affiliation? (c) What kind of lean was he? - Statesmalike ? - persistent - Chainer ? - political? (d) Family had pound (connections? (e) Graduate work at Haward ? (f) - FE - encouraged me to write agreed e July Goldstein is ( 1850-1926 - FE employers evolution of moden timefian (deate of cweligt). Science in 1860's - 1880's (Q) Bowditch in medicine at Housed (6) Psyclual reseach + the experimentation D Fera. - FE stressed cup revia of fain connectras. Boston as "Athers if America & all that extriled, lap expectation of